diff --git a/Makefile.tinydtls b/Makefile.tinydtls
index 0f303f4..0f6feb5 100644
--- a/Makefile.tinydtls
+++ b/Makefile.tinydtls
@@ -1,18 +1,6 @@
 # This is a -*- Makefile -*-
 
-ifeq ($(TARGET), redbee-econotag)
-CFLAGS += -DLITTLE_ENDIAN=3412 -DBYTE_ORDER=LITTLE_ENDIAN
-endif
-
-ifeq ($(TARGET), wismote)
-CFLAGS += -DLITTLE_ENDIAN=3412 -DBYTE_ORDER=LITTLE_ENDIAN
-endif
-
-ifeq ($(TARGET), exp5438)
-CFLAGS += -DLITTLE_ENDIAN=3412 -DBYTE_ORDER=LITTLE_ENDIAN
-endif
-
-CFLAGS += -DDTLSv12 -DWITH_SHA256 
+CFLAGS += -DDTLSv12 -DWITH_SHA256
 tinydtls_src = dtls.c crypto.c hmac.c rijndael.c sha2.c ccm.c netq.c ecc.c dtls_time.c peer.c session.c
 
 # This activates debugging support
diff --git a/platform-specific/config-cc2538dk.h b/platform-specific/config-cc2538dk.h
index 38bc85e..547a1b6 100644
--- a/platform-specific/config-cc2538dk.h
+++ b/platform-specific/config-cc2538dk.h
@@ -1,2 +1 @@
-#define BYTE_ORDER 1234
 #define HAVE_ASSERT_H 1
diff --git a/platform-specific/config-econotag.h b/platform-specific/config-econotag.h
index 38bc85e..547a1b6 100644
--- a/platform-specific/config-econotag.h
+++ b/platform-specific/config-econotag.h
@@ -1,2 +1 @@
-#define BYTE_ORDER 1234
 #define HAVE_ASSERT_H 1
diff --git a/platform-specific/config-sky.h b/platform-specific/config-sky.h
index f49ff3b..7f34972 100644
--- a/platform-specific/config-sky.h
+++ b/platform-specific/config-sky.h
@@ -1,3 +1,2 @@
-#define BYTE_ORDER 1234
 #define HAVE_ASSERT_H 1
 typedef int ssize_t;
diff --git a/platform-specific/platform.h b/platform-specific/platform.h
index 5bc42a4..dfc8b3e 100644
--- a/platform-specific/platform.h
+++ b/platform-specific/platform.h
@@ -61,6 +61,17 @@
 /** do not use uthash hash tables */
 #define DTLS_PEERS_NOHASH 1
 
+/* BYTE_ORDER definition for sha2 */
+#ifndef LITTLE_ENDIAN
+#define LITTLE_ENDIAN UIP_LITTLE_ENDIAN
+#endif
+#ifndef BIG_ENDIAN
+#define BIG_ENDIAN    UIP_BIG_ENDIAN
+#endif
+#ifndef UIP_BYTE_ORDER
+#define BYTE_ORDER    UIP_BYTE_ORDER
+#endif
+
 #ifndef SHA2_USE_INTTYPES_H
 #define SHA2_USE_INTTYPES_H 1
 #endif